HUBUNGAN KUADRATIK JUMLAH DAN LETAK SEED DENGAN DISTRIBUSI DOSIS I-125 BRACHYSEED PADA MODEL KANKER PROSTAT MENGGUNAKAN DOSE VOLUME HISTOGRAM

Junios Junios

Abstract


The aim of this study is to assess the variation effect of the amount and the location of seed  I-125 in dose absorbing behaviors of the target (prostate) and other organs at risk (bladder and rectum). The phantom model is 8x8x8 cm3 cube-shaped with 0.2x0.2x0.2 cm3 voxel size.   I-125 seeds are implanted into the prostate with variation of spacing and number. DOSXYZnrc is implemented to calculate doses.  To analyze dose distribution of each organ, the Dose Volume Histogram (DVH) program is developed using MATLAB. From this investigation, the effect of location of seeds influences the dose volume histogram for all organs. For example, the volume of prostate that receives 20% or more of the maximum dose (VB20) decrease around 40%, if the spacing among the seeds increases from 0.5 cm to 1 cm. But the spacing of seeds has insignificance effect on VB100 for each organ. This fenomena also appears if the number of seeds is changed. The spacing - and the number of seed have important role in the dose distribution not only on the target but also on the organs at risk. Therefore, the optimization for both parameters is needed.

Key words: Brachytherapy, Prostate, DOSXYZnrc, DVH


References


Badragan I and Sterian P. 2009. Space Phase Characteristic of A Typical I-125 Bra-chy Seed, Modelled By Monte Carlo Techniques. U.P.B Sci. Bull, Series A, Vol 71 (4): 81-88.

Baltas D and Zamboglou N. 2006. 2D and 3D Planning in Brachytheraphy, Springer, USA.

Guyton 1995. Fisiologi Manusia dan Meka-nisme Penyakit. Jakarta: EGC,.

Hartmann G. 2009. Nomenclature In Radio-therapy, Springer, USA.

Junios. Pengaruh Jumlah Seed Terhadap Dis-tribusi Dosis I.125 Brachyseed pada Model Kanker Prostat dengan Dose Volume Histogram. Vol. I. (34): 83-92.

Tabin SM and Zaidi H. 2003. Monte Carlo for use in theraupetic nuclear medicine. Institute of Physics Publishing.p: 133-153.

Mobit P and Badragan I. 2004. Dose perturb-bation effect in prostat seed implant brachytherapy with I-125, Institut of Physiscs Publishing, Physiscs in Medicine and Biology 49: 3171-3178.

Panitsa E, Rosenwald JC and Kappas C. 1998. Quality control of dose volume histogram computation characteristic. Physiscs Med. Biol. 43:2807-2816.




DOI: http://dx.doi.org/10.31958/js.v4i1.54

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